2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W716321
    AN7602
    AN7602 is a metabolite of the anti-inflammatory agent/PDE4 inhibitor Crisaborole (HY-10978) and can be used for the study of mild to moderate atopic dermatitis (AD).
    AN7602
  • HY-W012481S
    Nirvanol-d5
    Nirvanol-d5 (Ethylphenylhydantoin-d5) is deuterium labeled Nirvanol (HY-W012481). Nirvanol (Ethylphenylhydantoin) is a metabolite of Mephenytoin (HY-B1184) that exerts anticonvulsant effects in the maximal electroshock (M.E.S.) seizure model in mice. Nirvanol shows potential for research in epilepsy-related neurological disorders.
    Nirvanol-d<sub>5</sub>
  • HY-131263
    Hydroxychloroquine Impurity F
    Hydroxychloroquine Impurity F is the impurity of Hydroxychloroquine. Hydroxychloroquine is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine is efficiently inhibits SARS-CoV-2 infection in vitro.
    Hydroxychloroquine Impurity F
  • HY-128995
    Glycyl-Exatecan
    Glycyl-Exatecan (Glycyl-DX-8951) is an active metabolite released from DE-310 by enzymatic cleavage of the spacer. Glycyl-Exatecan exerts anti-tumor activity in vivo. Glycyl-Exatecan can be used for solid tumor research.
    Glycyl-Exatecan
  • HY-148375R
    Abiraterone sulfate (Standard)
    Bis(2-ethylhexyl) maleate (Standard) is the analytical standard of Bis(2-ethylhexyl) maleate. This product is intended for research and analytical applications. Bis(2-ethylhexyl) maleate can enhance the water sensitivity of polyvinyl acetate (PVAc) films and improve the tackiness, adhesion, and wash resistance of polyacrylate.
    Abiraterone sulfate (Standard)
  • HY-114750S
    Mebendazole-amine-13C6
    Mebendazole-amine-13C6 is the 13C6 labeled Mebendazole-amine. Mebendazole-amine is a metabolite of Mebendazole. Mebendazole is a broad-spectrum benzimidazole anti-helminthic agent.
    Mebendazole-amine-<sup>13</sup>C<sub>6</sub>
  • HY-70002BR
    Enzalutamide carboxylic acid (Standard)
    Bromoxynil octanoate (Standard) is the analytical standard of Bromoxynil octanoate. This product is intended for research and analytical applications. Bromoxynil octanoate is an herbicide widely applied to maize, is potentially toxic to both animals and humans.
    Enzalutamide carboxylic acid (Standard)
  • HY-133695S2
    Florfenicol amine-d5
    Florfenicol amine-d5 is the deuterium labeled Florfenicol amine (HY-133695). Florfenicol amine is a metabolite of Florfenicol (HY-B1374). Florfenicol, a veterinary antibiotic, can be used in aquaculture to control susceptible bacterial diseases.
    Florfenicol amine-d<sub>5</sub>
  • HY-167869
    A-849529
    A-849529 is an acid metabolite of ABT-869 (HY-50751). ABT-869 is a potent and orally active multi-target inhibitor of VEGFR and PDGFR family.
    A-849529
  • HY-179488
    (±)8(9)-EET
    (±)8(9)-EET is one of the main metabolites produced by the metabolism of arachidonic acid (HY-109590) through the cytochrome P450 epoxide pathway. (±)8(9)-EET is an effective substrate for COX-1 and COX-2. (±)8(9)-EET activates PPARα in HEK293 cells and inhibits the activity of NF-κB induced by IL-1β in a PPARα-dependent and -independent manner. The (8S,9R)-isomer of (±)8(9)-EET ([(8S,9R)-EET]) causes vasoconstriction, thereby reducing renal plasma flow and glomerular filtration rate.
    (±)8(9)-EET
  • HY-W748582
    Clozapine N-oxide-d8
    Clozapine N-oxide-d8 is the deuterium labeled Clozapine N-oxide (HY-17366). Clozapine N-oxide is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide can't cross the blood-brain barrier. Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC50=11 nM) agonist.
    Clozapine N-oxide-d<sub>8</sub>
  • HY-G0018R
    Norgestimate metabolite Norelgestromin (Standard)
    Norgestimate metabolite Norelgestromin (Standard) is the analytical standard of Norgestimate metabolite Norelgestromin. This product is intended for research and analytical applications.
    Norgestimate metabolite Norelgestromin (Standard)
  • HY-141621
    ACT-606559
    ACT-606559, a new chemical entity with antimalarial activity, is a metabolite of ACT451840. ACT-606559 can be used for the research of malarial.
    ACT-606559
  • HY-132143A
    7-Deaza-7-propargylamino-dATP tetralithium
    7-Deaza-7-propargylamino-dATP tetralithium is an analog of deoxyadenosine triphosphate (dATP) that can be used for gene sequencing.
    7-Deaza-7-propargylamino-dATP tetralithium
  • HY-124087R
    (±)-2-Propyl-4-pentenoic acid (Standard)
    (±)-2-Propyl-4-pentenoic acid (Standard) is the analytical standard of (±)-2-Propyl-4-pentenoic acid. This product is intended for research and analytical applications. (±)-2-Propyl-4-pentenoic acid (4-en-VPA) is a major toxic metabolite of Valproic acid. (±)-2-Propyl-4-pentenoic acid exhibits neuroteratogenicity[1][2].
    (±)-2-Propyl-4-pentenoic acid (Standard)
  • HY-144142S
    Orphenadrine impurity 6-d3 hydrochloride
    Orphenadrine impurity 6-d3 (hydrochloride) is the deuterium labeled Orphenadrine impurity 6 hydrochloride.
    Orphenadrine impurity 6-d<sub>3</sub> hydrochloride
  • HY-137083A
    Trifluoperazine N-glucuronide chloride
    Trifluoperazine N-glucuronide (UGT1A4) chloride is a metabolite of the antipsychotic agent trifluoperazine. Trifluoperazine N-glucuronide (UGT1A4) chloridecatalyzes the imipramine and trifluoperazine Nglucuronide formation.
    Trifluoperazine N-glucuronide chloride
  • HY-131254
    (S)-O-Desmethyl Venlafaxine N-Oxide
    (S)-O-Desmethyl Venlafaxine N-Oxide is a N-oxyde of (S)-O-Desmethyl Venlafaxine. O-Desmethyl Venlafaxine is an active metabolite of Venlafaxine. Venlafaxine (HY-B0196) is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class.
    (S)-O-Desmethyl Venlafaxine N-Oxide
  • HY-N15754
    3-Hydroxy-2-methylglutaric acid
    3-Hydroxy-2-methylglutaric acid is a carboxylic acid metabolite. 3-Hydroxy-2-methylglutaric acid can be isolated from the flower Veronica incana L. 3-Hydroxy-2-methylglutaric acid can be used for upper respiratory tract diseases, malignant neoplasms, gastrointestinal tract and genitourinary system disorders and diabetes mellitus research.
    3-Hydroxy-2-methylglutaric acid
  • HY-137577A
    (R)-Desmethylcitalopram oxalate
    (R)-Desmethylcitalopram oxalate is the metabolite of Citalopram (HY-121203). (R)-Desmethylcitalopram oxalate can be used for the research of neurological disease.
    (R)-Desmethylcitalopram oxalate
Cat. No. Product Name / Synonyms Application Reactivity